The Huntington Study Group (HSG) is a non-profit group of physicians and other health care providers from medical centers in the United States, Canada, Europe, Australia, New Zealand and South America, experienced in the care of Huntington patients and dedicated to clinical research of Huntington disease. The HSG was formed in 1993, prompted by the recognition that clinical research in Huntington disease (HD) required the participation of large numbers of research patients (subjects) under the cooperative care of skilled and experienced research physicians. The HSG aims to advance knowledge about the cause(s), disease progression and treatment of HD and related disorders. The HSG has carried out cooperative therapeutic research since 1993, beginning with the development of the Unified Huntington's Disease Rating Scale (UHDRS) and the Natural History database. Since then we have carried out several multi-center clinical research studies to examine the short-term symptomatic and potential disease-modifying effects of experimental interventions in Huntington disease as well as large observational studies. The HSG has partnered with pharmaceutical companies, private foundations, the National Institutes of Health (NIH) and the FDA Orphan Drug Products Division in developing and conducting these trials. Since our inception, we have published all of our research projects in internationally recognized peer-reviewed journals in an effort to make public all of our research progress in HD. Our publication list currently includes journal articles, abstracts, reports, releases and position papers.