Pioneering Medicines is focused on conceiving and developing a unique portfolio of life-changing treatments for patients by leveraging the innovative scientific platforms and technologies within the ecosystem of Flagship Pioneering companies. More than 40 companies across the Flagship ecosystem are creating and applying innovative approaches to help address major health and sustainability issues. Given the broad applicability of many Flagship platforms, there is a tremendous opportunity to expand the reach of these scientific innovations by creating medicines in disease areas where the companies are not yet focused. With access to all Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners. We also have the unique ability to combine these platforms in ways never before considered, harnessing the power of multiple Flagship scientific innovations and creating truly novel medicines. By identifying and pursuing opportunities earlier than the platform companies could focus on them and advancing these medicines through a robust discovery and early clinical development capability, Pioneering Medicines can reach patients across more disease areas much sooner than the individual platform companies could on their own.