The Materials Research Science & Engineering Center (MRSEC) at the University of Pennsylvania pursues a multidisciplinary approach to solve fundamental materials problems that are likely to underlie future technologies, and thereby, substantially impact the research and educational needs of society. The Laboratory for Research on the Structure of Matter (LRSM) is the intellectual focal point of materials research at PENN. It hosts the MRSEC, which consists of three Interdisciplinary Research Groups (IRGs) plus continually evolving Seed projects. The MRSEC provides crucial support for faculty, postdoctoral fellows, and graduate students drawn from different disciplines, to tackle complex materials science projects that can only be addressed in a truly collaborative mode. In this way, the MRSEC exploits PENN's strength in the design, synthesis, characterization, theory and modeling to create and understand entirely new classes of materials. The broad expertise, sophisticated equipment, plus the technical and administrative infrastructure that exist in the LRSM enable these projects. IRG1: Rearrangements & Softness in Disordered Solids IRG2: Structural Chemo-Mechanics of Fibrous Networks IRG3: Pluperfect Nanocrystal Architectures The LRSM plays a special role at PENN: It facilitates collaborations between faculty from different departments and schools, and it promotes links to partners in industry, government, academe, and society at large. The LRSM has experience in managing IRGs, nurturing Seed projects, and acquiring, building and maintaining shared experimental facilities for the benefit of the materials research community. The LRSM provides education & outreach in this "research" context and has moved aggressively in the area of human resources development through programs that target students at all levels from K-12 to post-docs, teachers, small college faculty, regional academic, industrial & gov. scientists, the intl. scientific comm., and the general public.