SMBs (Small Medium Sized Businesses) Profitability Leadership increases profitability and growth of companies by sharing knowledge on global risk management, organizational structure and organizational culture. The overall management of the risks you face as SMB, such as legality, liquidity, solvency, operational, credit, concentration, market, interest rate, exchange rate, reputation, financial and other extras contribute significantly to capture value and achieving the objectives of growth and profitability by improving the system of strategic and operational management. The implementation of the global risk management helps prioritize and select appropriate actions, identify potential risks, maximizing the chances of success and minimize the loss of opportunities, it is based on the best information available, adapts to available resources and the internal and external environment, facilitates continuous improvement of the organization, is transparent, participatory, dynamic, iterative and responsive to lead the changes of a SMB in a global environment. Organizational culture is a key element of organizational design, it is deeply rooted in all aspects of organizational life and affects the levels of competitiveness achieved by SMBs. The competitiveness of SMBs can be improved by changing the levels of the factors and organizational culture values, such as acceptance of the values of the organization by employees, development of subcultures and supporting change in the organization, identified as values of their culture, openness, flexibility, teamwork, creativity, learning and innovation.