The Center for Artificial Intelligence (C4AI) of the University of São Paulo, sponsored by IBM and FAPESP, is committed to state-of-art research in Artificial Intelligence (AI), exploring both foundational issues and applied research. The C4AI also supports studies on the social and economic impact of AI and carries activities aimed at technology transfer and knowledge diffusion, looking for ways to improve human well- being and to increase diversity and inclusion. The C4AI was established in 2020 through a large grant by IBM and FAPESP. The host institution is the Universidade de São Paulo, operating with partnering institutions ITA, PUC-SP and FEI. The Universidade de São Paulo matches the funding by supporting personnel and providing space for the C4AI activities. The C4AI is headquartered at InovaUSP, a space for multidisciplinary research and innovation at the heart of the Butantã campus of the Universidade de São Paulo. A second facility is located at the ICMC-USP in São Carlos. The C4AI is a member of IBM’s AI Horizons Network (AIHN), created in 2016 to promote collaboration amongst leading universities around the world to accelerate the research and applications of AI. The C4AI is part of the Engineering Research Centers Program of FAPESP where long-term funding is directed to key broad themes.