Since 2012, Maelstrom Research brings together an international team of epidemiologists, statisticians, and computer scientists to find practical solutions to the challenges faced by epidemiological research collaborations. Through the development of methods and open-source software, Maelstrom Research addresses the data documentation, dissemination, harmonization, and co-analysis needs of study investigators and research networks. In numerous international collaborations, Maelstrom Research has put to use its expertise to implement comprehensive data frameworks that foster and enhance the use of epidemiological study data. Years of experience working with and providing advice to partners from around the world has made Maelstrom Research a recognized leader in the field of methods and infrastructure development for collaborative research.