Recruitment costs are rapidly becoming a larger and larger portion of the overall study budget. Research Answers produces results at a significantly lower subject acquisition costs. We address the root causes of poor enrollment and share best practices of top performing research sites. Our cross-functional approach includes the following: • Early intervention to help sites address recruitment issues before the study start-up. • Protocol validation testing to estimate how large a patient population must be to meet enrollment projections and identify “problem” entry criteria that would significantly reduce enrollment. • Monitor training on best practice recruitment processes. • Technology tools that will assist sites with EMR to query their databases to quickly identify potential subjects. • Follow-up site training with site after enrollment initiation to keep a consistent focus on enrollment.