Established in 1995, the Detroit Community-Academic Urban Research Center (Detroit URC) is a collaboration of representatives from multiple Detroit organizations and academic researchers from the University of Michigan who work together to foster health equity in the city of Detroit. Through several different Detroit URC-affiliated partnerships and projects, we work in multiple communities in Detroit, characterized by differences in history, race and ethnicity, language, economic composition, and community organization. The Detroit URC Board, composed of representatives of each of the partner organizations, oversees all aspects of the Center in accordance with a set of CBPR principles adopted by the Detroit URC Board. The Detroit URC was funded originally through a Cooperative Agreement with the Centers for Disease Control and Prevention (CDC) through their Urban Research Centers Initiative, and now is supported by multiple federal and foundation grants and contributions from donors.